Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene
A sexual dimorphism in hypertension has been observed in both human and laboratory
animal studies. The mechanisms by which male sex hormones regulate cardiovascular
homeostasis are still not yet fully understood and represent the subject of this study. The
possible involvement of androgen receptors in the development of hypertension and end-
organ damage in transgenic rats harboring the mouse Ren-2 renin gene [TGR (mREN2) 27]
was studied. Male TGR (mREN2) 27 rats were treated with the androgen receptor antagonist …
animal studies. The mechanisms by which male sex hormones regulate cardiovascular
homeostasis are still not yet fully understood and represent the subject of this study. The
possible involvement of androgen receptors in the development of hypertension and end-
organ damage in transgenic rats harboring the mouse Ren-2 renin gene [TGR (mREN2) 27]
was studied. Male TGR (mREN2) 27 rats were treated with the androgen receptor antagonist …
