Effect of influenza virus infection on allergic sensitization to inhaled antigen in mice
PG Holt, J Vines, N Bilyk - International Archives of Allergy and …, 1988 - karger.com
PG Holt, J Vines, N Bilyk
International Archives of Allergy and Immunology, 1988•karger.comRepeated exposure of healthy mice to an aerosol of ovalbumen (OA) leads to the
development of IgE-isotype-specific immunological tolerance. However, when initial OA
exposure occurs during the acute phase of influenza infection, tolerance does not occur, and
the mice instead develop high titres of OA-specific IgE in response to subsequent challenge
with the allergen.
development of IgE-isotype-specific immunological tolerance. However, when initial OA
exposure occurs during the acute phase of influenza infection, tolerance does not occur, and
the mice instead develop high titres of OA-specific IgE in response to subsequent challenge
with the allergen.
Abstract
Repeated exposure of healthy mice to an aerosol of ovalbumen (OA) leads to the development of IgE-isotype-specific immunological tolerance. However, when initial OA exposure occurs during the acute phase of influenza infection, tolerance does not occur, and the mice instead develop high titres of OA-specific IgE in response to subsequent challenge with the allergen.
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