The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell
K Bialkowska, YQ Ma, K Bledzka… - Journal of biological …, 2010 - ASBMB
Integrin activation is crucial for numerous cellular responses, including cell adhesion,
migration, and survival. Recent studies in mice have specifically emphasized the vital role of
kindlin-3 in integrin activation. Kindlin-3 deficiency in humans also has now been
documented and includes symptoms of bleeding, frequent infections, and osteopetrosis,
which are consequences of an inability to activate β1, β2, and β3 integrins. To date, kindlin-3
was thought to be restricted to hematopoietic cells. In this article, we demonstrate that kindlin …
migration, and survival. Recent studies in mice have specifically emphasized the vital role of
kindlin-3 in integrin activation. Kindlin-3 deficiency in humans also has now been
documented and includes symptoms of bleeding, frequent infections, and osteopetrosis,
which are consequences of an inability to activate β1, β2, and β3 integrins. To date, kindlin-3
was thought to be restricted to hematopoietic cells. In this article, we demonstrate that kindlin …