Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells
J Boren, M Cascante, S Marin, B Comın-Anduix… - Journal of Biological …, 2001 - ASBMB
Chronic myeloid leukemia cells contain a constitutively active Bcr-Abl tyrosine kinase, the
target protein of Gleevec (STI571) phenylaminopyrimidine class protein kinase inhibitor.
Here we provide evidence for metabolic phenotypic changes in cultured K562 human
myeloid blast cells after treatment with increasing doses of STI571 using [1, 2-13 C 2]
glucose as the single tracer and biological mass spectrometry. In response to 0.68 and 6.8
μm STI571, proliferation of Bcr-Abl-positive K562 cells showed a 57% and 74% decrease …
target protein of Gleevec (STI571) phenylaminopyrimidine class protein kinase inhibitor.
Here we provide evidence for metabolic phenotypic changes in cultured K562 human
myeloid blast cells after treatment with increasing doses of STI571 using [1, 2-13 C 2]
glucose as the single tracer and biological mass spectrometry. In response to 0.68 and 6.8
μm STI571, proliferation of Bcr-Abl-positive K562 cells showed a 57% and 74% decrease …
