Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis
JR Krycer, AJ Brown - Journal of Biological Chemistry, 2011 - ASBMB
High cholesterol levels are associated with prostate cancer development. Androgens
promote cholesterol accumulation by activating the sterol-regulatory element-binding protein
isoform 2 (SREBP-2) transcription factor. However, SREBP-2 is in balance with the liver X
receptor (LXR; NR1H2/NR1H3), a transcription factor that prevents cholesterol
accumulation. Here, we show that LXR activity is down-regulated by the androgen receptor
(AR; NR3C4). In turn, this reduces LXR target gene expression. This antagonism on LXR is …
promote cholesterol accumulation by activating the sterol-regulatory element-binding protein
isoform 2 (SREBP-2) transcription factor. However, SREBP-2 is in balance with the liver X
receptor (LXR; NR1H2/NR1H3), a transcription factor that prevents cholesterol
accumulation. Here, we show that LXR activity is down-regulated by the androgen receptor
(AR; NR3C4). In turn, this reduces LXR target gene expression. This antagonism on LXR is …
