Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover
The 5HT-mediated contraction of rat thoracic aorta is competitively blocked by the specific
receptor antagonist 5HT 2 ketanserin. In this tissue the addition of 5HT activated the turnover
of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT 2 recognition sites
appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.
receptor antagonist 5HT 2 ketanserin. In this tissue the addition of 5HT activated the turnover
of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT 2 recognition sites
appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.
Abstract
The 5HT-mediated contraction of rat thoracic aorta is competitively blocked by the specific receptor antagonist 5HT2 ketanserin. In this tissue the addition of 5HT activated the turnover of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT2 recognition sites appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.
Elsevier
