Pimavanserin, a 5-HT2A receptor inverse agonist, reverses psychosis-like behaviors in a rodent model of Alzheimer's disease
DL Price, DW Bonhaus… - Behavioural Pharmacology, 2012 - journals.lww.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration in cognitive functioning. Overall, 25–50% of patients with AD also show
symptoms of psychosis including hallucinations and delusions. As all available antipsychotic
drugs have a 'black-box'warning for use in these patients because of increased mortality, no
appropriate treatment for psychotic symptoms in AD currently exists. In the present study, we
examined whether selective antagonism of 5-HT 2A serotonin receptors has antipsychotic …
deterioration in cognitive functioning. Overall, 25–50% of patients with AD also show
symptoms of psychosis including hallucinations and delusions. As all available antipsychotic
drugs have a 'black-box'warning for use in these patients because of increased mortality, no
appropriate treatment for psychotic symptoms in AD currently exists. In the present study, we
examined whether selective antagonism of 5-HT 2A serotonin receptors has antipsychotic …
