Cerebrospinal fluid concentrations of pterins and metabolites of serotonin and dopamine in a pediatric reference population
K Hyland, RAH Surtees, SJR Heales, A Bowron… - Pediatric …, 1993 - nature.com
K Hyland, RAH Surtees, SJR Heales, A Bowron, DW Howells, I Smith
Pediatric research, 1993•nature.comAccurate diagnosis and management of inborn errors of monoamine neurotransmitter and
tetrahydrobiopterin metabolism depend on reliable reference ranges of key metabolites.
Cerebrospinal fluid (CSF) was collected in a standardized way from 73 children and young
adults with neurologic disease, with strict exclusions. In each specimen, concentrations of
homovanillic acid (HVA), 5-hydroxyindoleacetic acid (HIAA), total neopterin, 7, 8-
dihydrobiopterin, and tetrahydrobiopterin (BH4) were measured using HPLC. There was a …
tetrahydrobiopterin metabolism depend on reliable reference ranges of key metabolites.
Cerebrospinal fluid (CSF) was collected in a standardized way from 73 children and young
adults with neurologic disease, with strict exclusions. In each specimen, concentrations of
homovanillic acid (HVA), 5-hydroxyindoleacetic acid (HIAA), total neopterin, 7, 8-
dihydrobiopterin, and tetrahydrobiopterin (BH4) were measured using HPLC. There was a …
Abstract
Accurate diagnosis and management of inborn errors of monoamine neurotransmitter and tetrahydrobiopterin metabolism depend on reliable reference ranges of key metabolites. Cerebrospinal fluid (CSF) was collected in a standardized way from 73 children and young adults with neurologic disease, with strict exclusions. In each specimen, concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (HIAA), total neopterin, 7, 8-dihydrobiopterin, and tetrahydrobiopterin (BH4) were measured using HPLC. There was a continuous decrement in CSF HVA, HIAA, and BH4 during the first few years of life; this was independent of height (or length). Age-related reference ranges for each metabolite are given. Extensive correlations between HVA, HIAA, 7, 8-dihydrobiopterin, and BH4 were further analyzed by multiple regression. Age and CSF BH4 were significant explanatory variables for CSF HIAA, but CSF HVA had only HIAA as a significant explanatory variable.
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