p38MAPK in the Senescence of Human and Murine Fibroblasts
F Debacq-Chainiaux, E Boilan, JD Le Moutier… - Protein Metabolism and …, 2010 - Springer
F Debacq-Chainiaux, E Boilan, JD Le Moutier, G Weemaels, O Toussaint
Protein Metabolism and Homeostasis in Aging, 2010•SpringerO ncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc,
can induce premature cellular senescence without critical telomere shortening. The role of
the Ras/Raf/ERK signal transduction cascade in this process has been previously
established, but recent evidence also indicates a critical role of the p38 MAP kinases
pathway. Oncogenic and environmental stresses impinge upon the p38 MAPK pathway,
suggesting a major role of this pathway in senescence induced by stresses. Prematurely …
can induce premature cellular senescence without critical telomere shortening. The role of
the Ras/Raf/ERK signal transduction cascade in this process has been previously
established, but recent evidence also indicates a critical role of the p38 MAP kinases
pathway. Oncogenic and environmental stresses impinge upon the p38 MAPK pathway,
suggesting a major role of this pathway in senescence induced by stresses. Prematurely …
Abstract
Oncogenic and environmental stresses, such as reactive oxygen species, UV radiation etc, can induce premature cellular senescence without critical telomere shortening. The role of the Ras/Raf/ERK signal transduction cascade in this process has been previously established, but recent evidence also indicates a critical role of the p38 MAP kinases pathway. Oncogenic and environmental stresses impinge upon the p38MAPK pathway, suggesting a major role of this pathway in senescence induced by stresses. Prematurely senescent cells are most likely to appear in several age-related pathologies associated with a stressful environment and/or the release of pro-inflammatory cytokines.
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