Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain
W Hirose, K Ikematsu, R Tsuda - Legal medicine, 2003 - Elsevier
Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to
biliverdin, free iron and carbon monoxide in the brain. Furthermore, the release of free
ferrous ion by HO-1 plays an essential role in ferritin synthesis, and ferritin stores iron either
for intracellular utilization, or for detoxification. It is well known that HO-1 immunoreactivity is
enhanced greatly in neurons and glia of the hippocampus and cerebral cortex in various
pathophysiological conditions. The expression of HSP 70 is well known for the age …
biliverdin, free iron and carbon monoxide in the brain. Furthermore, the release of free
ferrous ion by HO-1 plays an essential role in ferritin synthesis, and ferritin stores iron either
for intracellular utilization, or for detoxification. It is well known that HO-1 immunoreactivity is
enhanced greatly in neurons and glia of the hippocampus and cerebral cortex in various
pathophysiological conditions. The expression of HSP 70 is well known for the age …