The mechanisms responsible for prostate cancer metastasis are incompletely understood at
both the cellular and molecular levels. In this regard, chemokines are a family of small,
cytokine-like proteins that induce motility of neoplastic cells, leukocytes and cancer cells.
The current study evaluates the molecular mechanisms of CXCL12 and CXCR4 in prostate
cancer cell migration and invasion. We report that functional CXCR4 is significantly
expressed by prostate cancer cell lines, LNCaP and PC3, when compared with normal …