Adenylate cyclase/protein kinase A signaling pathway enhances angiogenesis through induction of vascular endothelial growth factor in vivo
H Amano, K Ando, S Minamida, I Hayashi… - Japanese journal of …, 2001 - Elsevier
We previously reported that endogenous prostaglandins (PGs) may increase cAMP
facilitated angiogenesis through the induction of vascular endothelial growth factor (VEGF)
in rat sponge implantation models. In the present experiment, we tested whether or not
adenylate cyclase/protein kinase A (AC/PKA)-dependent VEGF induction enhanced
angiogenesis in this model. Topical daily injections of 8-bromo-cAMP enhanced
angiogenesis in a dose-dependent manner. Forskolin, an activator of AC, also facilitated …
facilitated angiogenesis through the induction of vascular endothelial growth factor (VEGF)
in rat sponge implantation models. In the present experiment, we tested whether or not
adenylate cyclase/protein kinase A (AC/PKA)-dependent VEGF induction enhanced
angiogenesis in this model. Topical daily injections of 8-bromo-cAMP enhanced
angiogenesis in a dose-dependent manner. Forskolin, an activator of AC, also facilitated …
Cyclooxygenase‐2 and Adenylate Cyclase/Protein Kinase A Signaling Pathway Enhances Angiogenesis Through Induction of Vascular Endothelial Growth Factor in …
H Amano, I Haysahi, S Yoshida, H Yoshimura… - Human …, 2002 - Wiley Online Library
Angiogenesis is reportedly enhanced by prostaglandins (PGs). In the present experiment,
we tested whether or not COX‐2 and adenylate cyclase/protein kinase A (AC/PKA)‐
dependent VEGF induction enhanced angiogenesis in this model. Angiogenesis was
enhanced by topical injection of human recombinant basic fibroblast growth factor (bFGF).
The enhanced angiogenesis by bFGF was inhibited by indomethacin or selective COX‐2
inhibitors, NS398, nimesulide, and JTE‐522. Topical daily injections of 8‐bromo‐cAMP …
we tested whether or not COX‐2 and adenylate cyclase/protein kinase A (AC/PKA)‐
dependent VEGF induction enhanced angiogenesis in this model. Angiogenesis was
enhanced by topical injection of human recombinant basic fibroblast growth factor (bFGF).
The enhanced angiogenesis by bFGF was inhibited by indomethacin or selective COX‐2
inhibitors, NS398, nimesulide, and JTE‐522. Topical daily injections of 8‐bromo‐cAMP …