The idiosyncratic nature, severity and poor diagnosis of drug-induced liver injury (DILI) make
these reactions a major safety issue during drug development, as well as the most common
cause for the withdrawal of drugs from the pharmaceutical market. Elucidation of the
underlying mechanism (s) is necessary for identifying predisposing factors and developing
strategies in the treatment and prevention of DILI. Acetaminophen (APAP) is a widely used
over the counter therapeutic that is known to be effective and safe at therapeutic doses …