Mechanism of skin tumorigenesis by contact sensitizers: the effect of the corticosteroid fluocinolone acetonide on inflammation and tumor induction by 2, 4 dinitro-1 …

RE Albert, JE French, R Maronpot… - Environmental …, 1996 - ehp.niehs.nih.gov
The effect of the corticosteroid fluocinolone acetonide (FA) on skin tumor induction and
inflammation by the contact sensitizer dinitrofluorobenzene (DNFB) was examined. This
study broadly relates to the question of whether contact sensitizers, as electrophilic
chemicals that produce protein adduction, may constitute an environmental cancer hazard.
The specific aim of this study was to evaluate the extent to which the immunogenic
inflammatory response to DNFB, in contrast to DNFB cytotoxicity, might be responsible for …