[HTML][HTML] Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of rapamycin inhibition
AJ Zullo, S Lee - Journal of Biological Chemistry, 2012 - ASBMB
The interaction of host cells with mycobacteria is complex and can lead to multiple outcomes
ranging from bacterial clearance to latent infection. Although many factors are involved, the
mammalian autophagy pathway is recognized as a determinant that can influence the
course of infection. Intervention aimed at utilizing autophagy to clear infection requires an
examination of the autophagy and signal transduction induced by mycobacteria under
native conditions. With both pathogenic and non-pathogenic mycobacteria, we show that …
ranging from bacterial clearance to latent infection. Although many factors are involved, the
mammalian autophagy pathway is recognized as a determinant that can influence the
course of infection. Intervention aimed at utilizing autophagy to clear infection requires an
examination of the autophagy and signal transduction induced by mycobacteria under
native conditions. With both pathogenic and non-pathogenic mycobacteria, we show that …