The development of the embryonic outflow tract provides novel insights into cardiac differentiation and remodeling
Y Sugishita, M Watanabe, SA Fisher - Trends in cardiovascular medicine, 2004 - Elsevier
The embryonic cardiac outflow tract (OFT) connects the developing ventricles with the aortic
sac. In birds and mammals, OFT cardiomyocytes are generated from a “secondary
(anterior),” heart-forming field well after the formation of the primitive heart tube. The OFT
cardiomyocytes have unique properties and developmental fates as compared with the
myocytes of the atrial and ventricular chambers. Many of the OFT cardiomyocytes of the
avian embryo are eliminated by programmed cell death (PCD) during OFT remodeling in the …
sac. In birds and mammals, OFT cardiomyocytes are generated from a “secondary
(anterior),” heart-forming field well after the formation of the primitive heart tube. The OFT
cardiomyocytes have unique properties and developmental fates as compared with the
myocytes of the atrial and ventricular chambers. Many of the OFT cardiomyocytes of the
avian embryo are eliminated by programmed cell death (PCD) during OFT remodeling in the …