Different hepatocytes express the cholesterol 7α-hydroxylase gene during its circadian modulation in vivo
CM Berkowitz, CS Shen, BM Bilir, E Guibert… - Hepatology, 1995 - Elsevier
Cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile salt synthesis from cholesterol is
a P450 enzyme (CYP7A). Its expression and activity are regulated by bile salts, cholesterol,
hormones and a circadian modulator. Here we define the hepatocytes contributing to the
expression of the rat CYP7A gene during its in vivo circadian variation. The diurnal
expression of the CYP7A messenger RNA (mRNA) was studied by in situ hybridization and
correlated with the diurnal rate of CYP7A gene transcription and mRNA expression. At 10 …
a P450 enzyme (CYP7A). Its expression and activity are regulated by bile salts, cholesterol,
hormones and a circadian modulator. Here we define the hepatocytes contributing to the
expression of the rat CYP7A gene during its in vivo circadian variation. The diurnal
expression of the CYP7A messenger RNA (mRNA) was studied by in situ hybridization and
correlated with the diurnal rate of CYP7A gene transcription and mRNA expression. At 10 …