[HTML][HTML] A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes [S]
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis
in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1
mRNA via the 3′-untranslated region (3′-UTR). However, the underlying mechanism of
translational regulation of CYP7A1 mRNA remains unknown. Screening of a human micro
RNA (miRNA) microarray has identified five differentially expressed miRNAs in human
primary hepatocytes treated with chenodeoxycholic acid, GW4064, or fibroblast growth …
in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1
mRNA via the 3′-untranslated region (3′-UTR). However, the underlying mechanism of
translational regulation of CYP7A1 mRNA remains unknown. Screening of a human micro
RNA (miRNA) microarray has identified five differentially expressed miRNAs in human
primary hepatocytes treated with chenodeoxycholic acid, GW4064, or fibroblast growth …