Copper is essential for human physiology, but in excess it causes the severe metabolic
disorder Wilson disease. Elevated copper is thought to induce pathological changes in
tissues by stimulating the production of reactive oxygen species that damage multiple cell
targets. To better understand the molecular basis of this disease, we performed genome-
wide mRNA profiling as well as protein and metabolite analysis for Atp7b-/-mice, an animal
model of Wilson disease. We found that at the presymptomatic stages of the disease, copper …