[HTML][HTML] Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids
HU Marschall, M Wagner, K Bodin, G Zollner… - Journal of lipid …, 2006 - ASBMB
Farnesoid X receptor knockout (Fxr−/−) mice cannot upregulate the bile salt export pump in
bile acid loading or cholestatic conditions. To investigate whether Fxr−/− mice differ in bile
acid detoxification compared with wild-type mice, we performed a comprehensive analysis
of bile acids extracted from liver, bile, serum, and urine of naive and common bile duct-
ligated wild-type and Fxr−/− mice using electrospray and gas chromatography mass
spectrometry. In addition, hepatic and renal gene expression levels of Cyp2b10 and …
bile acid loading or cholestatic conditions. To investigate whether Fxr−/− mice differ in bile
acid detoxification compared with wild-type mice, we performed a comprehensive analysis
of bile acids extracted from liver, bile, serum, and urine of naive and common bile duct-
ligated wild-type and Fxr−/− mice using electrospray and gas chromatography mass
spectrometry. In addition, hepatic and renal gene expression levels of Cyp2b10 and …