Although bile acids are crucial for the absorption of lipophilic nutrients in the intestine, they
are cytotoxic at high concentrations and can cause liver damage and promote colorectal
carcinogenesis. The farnesoid X receptor (FXR), which is activated by bile acids and
abundantly expressed in enterohepatic tissues, plays a crucial role in maintaining bile acids
at safe concentrations. Here, we show that FXR induces expression of Akr1b7 (aldo-keto
reductase 1b7) in murine small intestine, colon, and liver by binding directly to a response …