Acetazolamide reduces the erythropoietin response to hypoxia at high altitude in humans
WH Reinhart, S Goerre, P Bärtsch - Journal of Wilderness Medicine, 1994 - Elsevier
Objective Acetazolamide, a carbonic anhydrase inhibitor, is often used as a prophylactic
drug for acute mountain sickness. It may interfere with erythropoietin production due to its
action on ventilation and renal function. Design A randomized, double-blind, placebo-
controlled trial with 2× 250 mg acetazolamide daily beginning one day before ascent from
590 m to 4559 m. Setting High-altitude research facilities at the Capanna Regina Margherita
(Italy) at an altitude of 4559 m. Participants Eighteen healthy volunteers, aged 24–42 years …
drug for acute mountain sickness. It may interfere with erythropoietin production due to its
action on ventilation and renal function. Design A randomized, double-blind, placebo-
controlled trial with 2× 250 mg acetazolamide daily beginning one day before ascent from
590 m to 4559 m. Setting High-altitude research facilities at the Capanna Regina Margherita
(Italy) at an altitude of 4559 m. Participants Eighteen healthy volunteers, aged 24–42 years …