The role of extracellular signal-related kinase during abdominal aortic aneurysm formation
A Ghosh, PD DiMusto, LK Ehrlichman, O Sadiq… - Journal of the American …, 2012 - Elsevier
BACKGROUND: It is hypothesized that activation of extracellular signal-related kinase
(ERK) is critical in activating matrix metalloproteinases (MMPs) during abdominal aortic
aneurysm (AAA) formation. STUDY DESIGN: C57BL/6 male mice underwent either elastase
or heat-inactivated elastase aortic perfusion (n= 9 per group). Mouse aortic smooth muscle
cells were transfected with ERK-1 and 2 siRNA along with or without elastase treatment.
Mouse and human aortic tissue were analyzed by Western blots, zymograms, and …
(ERK) is critical in activating matrix metalloproteinases (MMPs) during abdominal aortic
aneurysm (AAA) formation. STUDY DESIGN: C57BL/6 male mice underwent either elastase
or heat-inactivated elastase aortic perfusion (n= 9 per group). Mouse aortic smooth muscle
cells were transfected with ERK-1 and 2 siRNA along with or without elastase treatment.
Mouse and human aortic tissue were analyzed by Western blots, zymograms, and …
