Abdominal aortic aneurysms (AAAs) are common problems in aged people which can be
associated with severe complications including aortic rupture and death. Transforming
growth factor-β (TGFβ) has been implicated as causative in the development of thoracic
aortic aneurysms (TAAs). In contrast, current evidence suggests TGFβ inhibits AAA
development. Polymorphisms in the TGFβ signaling components are associated with AAA in
some human population studies. In experimental animals TGFβ protects against AAA …