[HTML][HTML] Regulation of protein function and signaling by reversible cysteine S-nitrosylation
NO is a versatile free radical that mediates numerous biological functions within every major
organ system. A molecular pathway by which NO accomplishes functional diversity is the
selective modification of protein cysteine residues to form S-nitrosocysteine. This post-
translational modification, S-nitrosylation, impacts protein function, stability, and location.
Despite considerable advances with individual proteins, the in vivo biological chemistry, the
structural elements that govern the selective S-nitrosylation of cysteine residues, and the …
organ system. A molecular pathway by which NO accomplishes functional diversity is the
selective modification of protein cysteine residues to form S-nitrosocysteine. This post-
translational modification, S-nitrosylation, impacts protein function, stability, and location.
Despite considerable advances with individual proteins, the in vivo biological chemistry, the
structural elements that govern the selective S-nitrosylation of cysteine residues, and the …