[HTML][HTML] Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators
SL Goh, Y Looi, H Shen, J Fang, C Bodner… - Journal of biological …, 2009 - ASBMB
The transcription factor encoded by the murine ecotropic integration site 1 gene (MEIS1) is a
partner of HOX and PBX proteins. It has been implicated in embryonic patterning and
leukemia, and causally linked to restless legs syndrome. The MEIS1A C terminus harbors a
transcriptional activation domain that is stimulated by protein kinase A (PKA) in a manner
dependent on the co-activator of cAMP response element-binding protein (CREB), CREB-
binding protein (CBP). We explored the involvement of another mediator of PKA-inducible …
partner of HOX and PBX proteins. It has been implicated in embryonic patterning and
leukemia, and causally linked to restless legs syndrome. The MEIS1A C terminus harbors a
transcriptional activation domain that is stimulated by protein kinase A (PKA) in a manner
dependent on the co-activator of cAMP response element-binding protein (CREB), CREB-
binding protein (CBP). We explored the involvement of another mediator of PKA-inducible …
