[HTML][HTML] A direct β-catenin-independent interaction between androgen receptor and T cell factor 4
AL Amir, M Barua, NC McKnight, S Cheng… - Journal of Biological …, 2003 - ASBMB
T cell factor (Tcf) proteins bind β-catenin and are downstream effectors of Wnt/β-catenin
signals. A recently demonstrated interaction between β-catenin and the androgen receptor
(AR) ligand binding domain has suggested that AR may be a Tcf-independent Wnt/β-catenin
effector. This study demonstrates that there is a direct interaction between the AR DNA
binding domain (DBD) and Tcf4. Tcf4 bound specifically to a glutathione S-transferase-
ARDBD fusion protein and could be coimmunoprecipitated with β-catenin and transfected …
signals. A recently demonstrated interaction between β-catenin and the androgen receptor
(AR) ligand binding domain has suggested that AR may be a Tcf-independent Wnt/β-catenin
effector. This study demonstrates that there is a direct interaction between the AR DNA
binding domain (DBD) and Tcf4. Tcf4 bound specifically to a glutathione S-transferase-
ARDBD fusion protein and could be coimmunoprecipitated with β-catenin and transfected …
