Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
IWY Mak, EP Seidlitz, RW Cowan, RE Turcotte… - Human pathology, 2010 - Elsevier
Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is
characterized by the presence of abundant multinucleated osteoclast-like giant cells,
hematopoietic monocytes, and a distinct mesenchymal stromal cell component. Previous
work in our laboratory has shown that matrix metalloproteinase (MMP)-13 is the principal
proteinase expressed by the stromal cells of GCT. The release of cytokines, particularly
interleukin-1β, by the giant cells of GCT acts on stromal cells to stimulate a surge in MMP-13 …
characterized by the presence of abundant multinucleated osteoclast-like giant cells,
hematopoietic monocytes, and a distinct mesenchymal stromal cell component. Previous
work in our laboratory has shown that matrix metalloproteinase (MMP)-13 is the principal
proteinase expressed by the stromal cells of GCT. The release of cytokines, particularly
interleukin-1β, by the giant cells of GCT acts on stromal cells to stimulate a surge in MMP-13 …
