Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases
involved in the degradation and remodeling of extracellular matrix in physiological and
pathological processes. MMPs also have a role in cell proliferation, migration, differentiation,
angiogenesis, and apoptosis. We previously identified cancer invasion-related factors by
comparing the gene expression profiles between parent and the highly invasive clone of
cancer cells. Matrix metalloproteinase-13 (MMP-13) was identified as a common up …