Regulation of potassium (K) handling in the renal collecting duct

WH Wang, G Giebisch - Pflügers Archiv-European Journal of Physiology, 2009 - Springer
WH Wang, G Giebisch
Pflügers Archiv-European Journal of Physiology, 2009Springer
This review provides an overview of the molecular mechanisms of K transport in the
mammalian connecting tubule (CNT) and cortical collecting duct (CCD), both nephron
segments responsible for the regulation of renal K secretion. Aldosterone and dietary K
intake are two of the most important factors regulating K secretion in the CNT and CCD.
Recently, angiotensin II (AngII) has also been shown to play a role in the regulation of K
secretion. In addition, genetic and molecular biological approaches have further identified …
Abstract
This review provides an overview of the molecular mechanisms of K transport in the mammalian connecting tubule (CNT) and cortical collecting duct (CCD), both nephron segments responsible for the regulation of renal K secretion. Aldosterone and dietary K intake are two of the most important factors regulating K secretion in the CNT and CCD. Recently, angiotensin II (AngII) has also been shown to play a role in the regulation of K secretion. In addition, genetic and molecular biological approaches have further identified new mechanisms by which aldosterone and dietary K intake regulate K transport. Thus, the interaction between serum-glucocorticoid-induced kinase 1 (SGK1) and with-no-lysine kinase 4 (WNK4) plays a significant role in mediating the effect of aldosterone on ROMK (Kir1.1), an important apical K channel modulating K secretion. Recent evidence suggests that WNK1, mitogen-activated protein kinases such as P38, ERK, and Src family protein tyrosine kinase are involved in mediating the effect of low K intake on apical K secretory channels.
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