[HTML][HTML] Rab5-stimulated up-regulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ …
OM Grbovic, PM Mathews, Y Jiang, SD Schmidt… - Journal of Biological …, 2003 - ASBMB
We previously identified abnormalities of the endocytic pathway in neurons as the earliest
known pathology in sporadic Alzheimer's disease (AD) and Down's syndrome brain. In this
study, we modeled aspects of these AD-related endocytic changes in murine L cells by
overexpressing Rab5, a positive regulator of endocytosis. Rab5-transfected cells exhibited
abnormally large endosomes immunoreactive for Rab5 and early endosomal antigen 1,
resembling the endosome morphology seen in affected neurons from AD brain. The levels of …
known pathology in sporadic Alzheimer's disease (AD) and Down's syndrome brain. In this
study, we modeled aspects of these AD-related endocytic changes in murine L cells by
overexpressing Rab5, a positive regulator of endocytosis. Rab5-transfected cells exhibited
abnormally large endosomes immunoreactive for Rab5 and early endosomal antigen 1,
resembling the endosome morphology seen in affected neurons from AD brain. The levels of …
