Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates

AB Malmberg, AI Basbaum - Pain, 1998 - Elsevier
The generation of knock-out and transgenic mice offers a promising approach to the
identification of novel biochemical factors that contribute to persistent pain conditions. To
take advantage of these mice, however, it is important to demonstrate that the traditional
models of persistent pain, which were largely developed for studies in the rat, can be used in
the mouse. Here, we combined behavioral and anatomical methods to characterize the
pathophysiology of a partial nerve injury-evoked pain condition in thenormal'mouse. In male …