[HTML][HTML] Broader expression of the mouse platelet factor 4‐cre transgene beyond the megakaryocyte lineage
F Pertuy, A Aguilar, C Strassel, A Eckly… - Journal of Thrombosis …, 2015 - Elsevier
Background Transgenic mice expressing cre recombinase under the control of the platelet
factor 4 (Pf4) promoter, in the context of a 100‐kb bacterial artificial chromosome, have
become a valuable tool with which to study genetic modifications in the platelet lineage.
However, the specificity of cre expression has recently been questioned, and the time of its
onset during megakaryopoiesis remains unknown. Objectives/Methods To characterize the
expression of this transgene, we used double‐fluorescent cre reporter mice. Results In the …
factor 4 (Pf4) promoter, in the context of a 100‐kb bacterial artificial chromosome, have
become a valuable tool with which to study genetic modifications in the platelet lineage.
However, the specificity of cre expression has recently been questioned, and the time of its
onset during megakaryopoiesis remains unknown. Objectives/Methods To characterize the
expression of this transgene, we used double‐fluorescent cre reporter mice. Results In the …
