Study objectives Marked variability exists in coronary artery collaterals in patients with
ischemic heart disease. Although multiple factors are thought to play a role in collateral
development, the contribution of genetic factors is largely unknown. Hypoxia inducible factor
1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen
homeostasis, is one possible genetic factor that could play an important role in modulating
collateral development Design, setting, and participants Collateral vessels were determined …