Anti-vascular endothelial growth factor treatment induces blood flow recovery through vascular remodeling in high-fat diet induced diabetic mice
L Xiao, K Yan, Y Yang, N Chen, Y Li, X Deng… - Microvascular …, 2016 - Elsevier
Diabetes mellitus (DM) leads to the development of microvascular diseases and is
associated with impaired angiogenesis. The presence of vascular endothelial growth factor
(VEGF) can block PDGF-BB dependent regulation of neovascularization and vessel
normalization. We tested the hypothesis that the inhibition of VEGF improves blood flow in a
mouse hindlimb ischemia model produced by femoral artery ligation. In this study, we
examined the effect of bevacizumab, a humanized monoclonal antibody against VEGF-A, on …
associated with impaired angiogenesis. The presence of vascular endothelial growth factor
(VEGF) can block PDGF-BB dependent regulation of neovascularization and vessel
normalization. We tested the hypothesis that the inhibition of VEGF improves blood flow in a
mouse hindlimb ischemia model produced by femoral artery ligation. In this study, we
examined the effect of bevacizumab, a humanized monoclonal antibody against VEGF-A, on …