Effect of targeting inflammation with salsalate: the TINSAL-CVD randomized clinical trial on progression of coronary plaque in overweight and obese patients using …
TH Hauser, N Salastekar, EJ Schaefer, T Desai… - JAMA …, 2016 - jamanetwork.com
Importance Inflammation may contribute to pathological associations among obesity,
diabetes mellitus, and cardiovascular disease. Objective To determine whether targeting
inflammation using salsalate compared with placebo reduces progression of noncalcified
coronary artery plaque. Design, Setting, and Participants In the Targeting Inflammation
Using Salsalate in Cardiovascular Disease (TINSAL-CVD) trial participants were randomly
assigned between September 23, 2008, and July 5, 2012, to 30 months of salsalate or …
diabetes mellitus, and cardiovascular disease. Objective To determine whether targeting
inflammation using salsalate compared with placebo reduces progression of noncalcified
coronary artery plaque. Design, Setting, and Participants In the Targeting Inflammation
Using Salsalate in Cardiovascular Disease (TINSAL-CVD) trial participants were randomly
assigned between September 23, 2008, and July 5, 2012, to 30 months of salsalate or …