Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial
AD Pradhan, BM Everett, NR Cook, N Rifai, PM Ridker - Jama, 2009 - jamanetwork.com
Context As diabetes is in part an inflammatory condition, the initiation of insulin and/or
metformin may beneficially reduce levels of inflammatory biomarkers such as high-sensitivity
C-reactive protein (hsCRP). Objective To determine whether insulin alone or combined with
metformin lowers levels of hsCRP, IL-6, and soluble tumor necrosis factor receptor 2
(sTNFr2) in patients with recent-onset type 2 diabetes mellitus. Design, Setting, and
Participants Randomized 2× 2 factorial trial of open-label insulin glargine and placebo …
metformin may beneficially reduce levels of inflammatory biomarkers such as high-sensitivity
C-reactive protein (hsCRP). Objective To determine whether insulin alone or combined with
metformin lowers levels of hsCRP, IL-6, and soluble tumor necrosis factor receptor 2
(sTNFr2) in patients with recent-onset type 2 diabetes mellitus. Design, Setting, and
Participants Randomized 2× 2 factorial trial of open-label insulin glargine and placebo …