[HTML][HTML] Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

KF Petersen, EA Oral, S Dufour… - The Journal of …, 2002 - Am Soc Clin Investig
KF Petersen, EA Oral, S Dufour, D Befroy, C Ariyan, C Yu, GW Cline, AM DePaoli, SI Taylor
The Journal of clinical investigation, 2002Am Soc Clin Investig
Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and
visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered
glucose metabolism. It has recently been shown that chronic leptin treatment ameliorates
these abnormalities. Here we show that chronic leptin treatment improves insulin-stimulated
hepatic and peripheral glucose metabolism in severely insulin-resistant lipodystrophic
patients. This improvement in insulin action was associated with a marked reduction in …
Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered glucose metabolism. It has recently been shown that chronic leptin treatment ameliorates these abnormalities. Here we show that chronic leptin treatment improves insulin-stimulated hepatic and peripheral glucose metabolism in severely insulin-resistant lipodystrophic patients. This improvement in insulin action was associated with a marked reduction in hepatic and muscle triglyceride content. These data suggest that leptin may represent an important new therapy to reverse the severe hepatic and muscle insulin resistance and associated hepatic steatosis in patients with lipodystrophy.
The Journal of Clinical Investigation