[HTML][HTML] Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue

RA Koza, SM Hohmann, C Guerra, M Rossmeisl… - Journal of Biological …, 2000 - ASBMB
Among a selected group of mouse strains susceptible to dietary obesity, those with an
enhanced capacity forUcp1 and brown adipocyte induction in white fat preferentially lost
body weight following adrenergic stimulation. Based on the generality of this mechanism for
reducing obesity, a genetic analysis was initiated to identify genes that control brown
adipocyte induction in white fat depots in mice. Quantitative trait locus (QTL) analysis was
performed using the variations of retroperitoneal fatUcp1 mRNA expression in progeny of …