Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

C McDonald-Hyman, LA Turka, BR Blazar - Science translational …, 2015 - science.org
C McDonald-Hyman, LA Turka, BR Blazar
Science translational medicine, 2015science.org
Although major advances have been made in solid organ and hematopoietic stem cell
transplantation in the last 50 years, big challenges remain. This review outlines the current
immunological limitations for hematopoietic stem cell and solid organ transplantation and
discusses new immune-modulating therapies in preclinical development and in clinical trials
that may allow these obstacles to be overcome.
Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.
AAAS