Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

MR Clark, M Mandal, K Ochiai, H Singh - Nature Reviews Immunology, 2014 - nature.com
MR Clark, M Mandal, K Ochiai, H Singh
Nature Reviews Immunology, 2014nature.com
The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a
crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy
chain before commitment to rearrangement and expression of an immunoglobulin light
chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light
chain recombination and their differentiation into B cells. Recent advances have revealed …
Abstract
The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.
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