[HTML][HTML] Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn′ s disease

N Inohara, Y Ogura, A Fontalba, O Gutierrez… - Journal of Biological …, 2003 - ASBMB
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to
bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety
recognized remains elusive. Biochemical and functional analyses identified muramyl
dipeptide (MurNAc-l-Ala-d-isoGln) derived from peptidoglycan as the essential structure in
bacteria recognized by NOD2. Replacement of l-Ala for d-Ala ord-isoGln for l-isoGln
eliminated the ability of muramyl dipeptide to stimulate NOD2, indicating stereoselective …