Gating and modulation of presumptive NaV1. 9 channels in enteric and spinal sensory neurons

B Coste, N Osorio, F Padilla, M Crest… - Molecular and Cellular …, 2004 - Elsevier
The NaV1. 9 subunit is expressed in nociceptive dorsal root ganglion (DRG) neurons and
sensory myenteric neurons in which it generates 'persistent'tetrodotoxin-resistant (TTX-R)
Na+ currents of yet unknown physiological functions. Here, we have analyzed these currents
in details by combining single-channel and whole-cell recordings from cultured rat DRG and
myenteric neurons. Comparison of single-channel with whole-cell data indicates that
recording using internal CsCl best reflects the basic electrical features of NaV1. 9 currents …