Bone morphogenetic protein-4: a novel therapeutic target for pathological cardiac hypertrophy/heart failure

WT Guo, DL Dong - Heart failure reviews, 2014 - Springer
WT Guo, DL Dong
Heart failure reviews, 2014Springer
Abstract Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic
protein family which plays a key role in the bone formation and embryonic development. In
addition to these predominate and well-studied effects, the growing evidences highlight
BMP4 as an important factor in cardiovascular diseases, such as hypertension, pulmonary
hypertension and valve disease. Our recent works demonstrated that BMP4 mediated
cardiac hypertrophy, apoptosis, fibrosis and ion channel remodeling in pathological cardiac …
Abstract
Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays a key role in the bone formation and embryonic development. In addition to these predominate and well-studied effects, the growing evidences highlight BMP4 as an important factor in cardiovascular diseases, such as hypertension, pulmonary hypertension and valve disease. Our recent works demonstrated that BMP4 mediated cardiac hypertrophy, apoptosis, fibrosis and ion channel remodeling in pathological cardiac hypertrophy. In this review, we discussed the role of BMP4 in pathological cardiac hypertrophy, as well as the recent advances about BMP4 in cardiovascular diseases closely related to pathological cardiac hypertrophy/heart failure. We put forward that BMP4 is a novel therapeutic target for pathological cardiac hypertrophy/heart failure.
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