[HTML][HTML] Increased frequencies of Th17 in the peripheral blood of patients with chronic lymphocytic leukemia: A one year follow-up
D Tang, Q Niu, N Jiang, J Li, Q Zheng… - Pakistan journal of …, 2014 - ncbi.nlm.nih.gov
D Tang, Q Niu, N Jiang, J Li, Q Zheng, Y Jia
Pakistan journal of medical sciences, 2014•ncbi.nlm.nih.govObjective: In this study, we aimed to investigate changes of peripheral Th17 and Treg cells
frequencies in the newly-diagnosed Chronic Lymphocytic Leukemia (CLL) patients for 12
months. Methods: In this research, 50 CLL patients were enrolled. Circulating Th1, Th17
cells and CD4+ CD25+ Foxp3+ Treg cells were analyzed by flow cytometry. Plasma levels of
related cytokines were detected by enzyme-linked immuno sorbent assay (ELISA). The
study was carried out from January 2012 to October 2013 at Department of Laboratory …
frequencies in the newly-diagnosed Chronic Lymphocytic Leukemia (CLL) patients for 12
months. Methods: In this research, 50 CLL patients were enrolled. Circulating Th1, Th17
cells and CD4+ CD25+ Foxp3+ Treg cells were analyzed by flow cytometry. Plasma levels of
related cytokines were detected by enzyme-linked immuno sorbent assay (ELISA). The
study was carried out from January 2012 to October 2013 at Department of Laboratory …
Abstract
Objective: In this study, we aimed to investigate changes of peripheral Th17 and Treg cells frequencies in the newly-diagnosed Chronic Lymphocytic Leukemia (CLL) patients for 12 months.
Methods: In this research, 50 CLL patients were enrolled. Circulating Th1, Th17 cells and CD4+ CD25+ Foxp3+ Treg cells were analyzed by flow cytometry. Plasma levels of related cytokines were detected by enzyme-linked immuno sorbent assay (ELISA). The study was carried out from January 2012 to October 2013 at Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, PR China.
Results: Compared with healthy controls, Th17 cells related cytokines were significantly increased in CLL patients, while Treg cells related cytokines were significantly lowered. In the follow-up, we found that the frequency of Treg cells was irregular, while the frequency of Th17 cells was gradually decreased.
Conclusion: Our study suggested that Th17 cells may play important role in the immune regulation of CLL, and may become a new target in CLL therapy.
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