The prenatal origins of cancer
GM Marshall, DR Carter, BB Cheung, T Liu… - Nature Reviews …, 2014 - nature.com
Nature Reviews Cancer, 2014•nature.com
The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver
mutations and embryonal and early postnatal development. This evidence, coupled with
much greater detail on the cell of origin and the initial steps in embryonal cancer initiation,
has identified important therapeutic targets and provided renewed interest in strategies for
the early detection and prevention of childhood cancer.
cells has a long history. Recent research has strengthened the links between driver
mutations and embryonal and early postnatal development. This evidence, coupled with
much greater detail on the cell of origin and the initial steps in embryonal cancer initiation,
has identified important therapeutic targets and provided renewed interest in strategies for
the early detection and prevention of childhood cancer.
Abstract
The concept that some childhood malignancies arise from postnatally persistent embryonal cells has a long history. Recent research has strengthened the links between driver mutations and embryonal and early postnatal development. This evidence, coupled with much greater detail on the cell of origin and the initial steps in embryonal cancer initiation, has identified important therapeutic targets and provided renewed interest in strategies for the early detection and prevention of childhood cancer.
nature.com