N‐myc is frequently activated by proviral insertion in MuLV‐induced T cell lymphomas.
M van Lohuizen, M Breuer, A Berns - The EMBO journal, 1989 - embopress.org
M van Lohuizen, M Breuer, A Berns
The EMBO journal, 1989•embopress.orgWe report a new common proviral insertion site in murine leukemia virus‐induced T cell
lymphomas to be N‐myc. Proviral activation of N‐myc was found in 35% of independently
induced primary tumors. The vast majority of the proviral insertions occur within a small
segment of the 3′‐untranslated region of the N‐myc gene, directly downstream of the
protein‐encoding domain. This results in an increased level of expression of a truncated N‐
myc mRNA. Together with the previously shown c‐myc activation we now find involvement …
lymphomas to be N‐myc. Proviral activation of N‐myc was found in 35% of independently
induced primary tumors. The vast majority of the proviral insertions occur within a small
segment of the 3′‐untranslated region of the N‐myc gene, directly downstream of the
protein‐encoding domain. This results in an increased level of expression of a truncated N‐
myc mRNA. Together with the previously shown c‐myc activation we now find involvement …
We report a new common proviral insertion site in murine leukemia virus‐induced T cell lymphomas to be N‐myc. Proviral activation of N‐myc was found in 35% of independently induced primary tumors. The vast majority of the proviral insertions occur within a small segment of the 3′‐untranslated region of the N‐myc gene, directly downstream of the protein‐encoding domain. This results in an increased level of expression of a truncated N‐myc mRNA. Together with the previously shown c‐myc activation we now find involvement of myc genes in greater than 75% of the primary T cell lymphomas induced by Moloney murine leukemia virus in C57BL10 and BALB/c mice, and show for the first time that N‐myc can be over‐expressed by a mechanism other than gene amplification.
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