[HTML][HTML] A major histocompatibility complex· peptide-restricted antibody and T cell receptor molecules recognize their target by distinct binding modes: crystal structure …
M Hulsmeyer, P Chames, RC Hillig, RL Stanfield… - Journal of Biological …, 2005 - ASBMB
Antibodies with T cell receptor-like specificity possess a considerable diagnostic and
therapeutic potential, but the structural basis of the interaction between an antibody and an
histocompatibility antigen has so far not been determined. We present here the crystal
structure (at 2.15 Å resolution) of the recombinant, affinity-matured human antibody
fragment Fab-Hyb3 bound to the tumor-associated human leukocyte antigen (HLA)/peptide
complex HLA-A1· MAGE-A1. Fab-Hyb3 employs a diagonal docking mode resembling that …
therapeutic potential, but the structural basis of the interaction between an antibody and an
histocompatibility antigen has so far not been determined. We present here the crystal
structure (at 2.15 Å resolution) of the recombinant, affinity-matured human antibody
fragment Fab-Hyb3 bound to the tumor-associated human leukocyte antigen (HLA)/peptide
complex HLA-A1· MAGE-A1. Fab-Hyb3 employs a diagonal docking mode resembling that …