A high-avidity WT1-reactive T-cell receptor mediates recognition of peptide and processed antigen but not naturally occurring WT1-positive tumor cells
A Jaigirdar, SA Rosenberg… - Journal of …, 2016 - journals.lww.com
Abstract Wilms tumor gene 1 (WT1) is an attractive target antigen for cancer immunotherapy
because it is overexpressed in many hematologic malignancies and solid tumors but has
limited, low-level expression in normal adult tissues. Multiple HLA class I and class II
restricted epitopes have been identified in WT1, and multiple investigators are pursuing the
treatment of cancer patients with WT1-based vaccines and adoptively transferred WT1-
reactive T cells. Here we isolated an HLA-A* 0201-restricted WT1-reactive T-cell receptor …
because it is overexpressed in many hematologic malignancies and solid tumors but has
limited, low-level expression in normal adult tissues. Multiple HLA class I and class II
restricted epitopes have been identified in WT1, and multiple investigators are pursuing the
treatment of cancer patients with WT1-based vaccines and adoptively transferred WT1-
reactive T cells. Here we isolated an HLA-A* 0201-restricted WT1-reactive T-cell receptor …
