Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice
S Jiang, S Han, J Chen, X Li, H Che - Annals of Allergy, Asthma & …, 2017 - Elsevier
Background Notch signaling regulates proliferation, differentiation, and function of dendritic
cells, T cells, and mast cells, as well as many other immune cells, which act as important
parts in food allergy, Notch signaling may play an important role in food allergy. Objective To
investigate the role of Notch signaling in IgE-mediated food allergy. Methods An ovalbumin-
induced food allergy mouse model was built (cholera toxin as adjuvant) and Notch signaling
was blunted by FLI-06 and MW167, which inhibited Notch receptor–expressing phase and …
cells, T cells, and mast cells, as well as many other immune cells, which act as important
parts in food allergy, Notch signaling may play an important role in food allergy. Objective To
investigate the role of Notch signaling in IgE-mediated food allergy. Methods An ovalbumin-
induced food allergy mouse model was built (cholera toxin as adjuvant) and Notch signaling
was blunted by FLI-06 and MW167, which inhibited Notch receptor–expressing phase and …
